{"id":1367,"date":"2023-02-08T13:23:10","date_gmt":"2023-02-08T13:23:10","guid":{"rendered":"https:\/\/xlab-stiftung.de\/?page_id=1367"},"modified":"2023-02-08T13:23:11","modified_gmt":"2023-02-08T13:23:11","slug":"sf-2011-drug-development-in-the-21st-century-are-we-going-to-cure-all-diseases","status":"publish","type":"page","link":"https:\/\/xlab-stiftung.de\/en\/science-festival-2004-2017-2\/sf-2011-drug-development-in-the-21st-century-are-we-going-to-cure-all-diseases\/","title":{"rendered":"SF-2011-Drug Development in the 21st century \u2013 are we going to cure all diseases"},"content":{"rendered":"<p><em>Prof. MD. DSc. Aaron Ciechanover<br>Technion \u2013 Israel Institute of Technology Haifa, Israel<\/em><\/p>\n\n\n\n<p>Many important drugs such as penicillin, aspirin, or digitalis, were discovered by serendipity \u2014 some by curious researchers who noted an accidental phenomenon, some by isolation of active ingredients from plants known for centuries to have a specific therapeutic effect. Other major drugs like statins were discovered using more advanced technologies, such as targeted screening, yet, the discoverers were looking for a different effect. In all these cases, the mechanisms of action of the drug were largely unknown at the time of their discovery, and were discovered only later. With the realization that not all patients with diseases that physically and histopathologically appear to be the same \u2014 different malignancies for example \u2014 respond similarly to treatment, and their clinical behavior is different, we have begun to understand that their molecular basis is distinct. Accordingly, we are exiting the era where our approach to treatment is \u201cone size fits all\u201d, and enter a new one of \u201cpersonalized medicine\u201d where we shall tailor the treatment according to the patient\u2019s molecular\/mutational profile. Here, unlike the previous era, the understanding of the mechanism will drive the development of the new drugs. This era will be characterized the development of technologies where sequencing and processing of individual genomes will be cheap (US$ &lt;1,000) and fast (a few minutes), by identification and characterization of new disease-specific molecular markers and drug targets, and by design of novel, mechanism-based, drugs to modulate the activities of these targets. It will require a change in our approach to scientific research and development and to education, where interdisciplinarity will domineer and replace in many ways the traditional, discipline-oriented approach.<br>Aaron Ciechanover wurde 2004 mit dem Nobelpreis f\u00fcr Chemie ausgezeichnet.<\/p>","protected":false},"excerpt":{"rendered":"<p>Prof. MD. DSc. Aaron CiechanoverTechnion \u2013 Israel Institute of Technology Haifa, Israel Many important drugs such as penicillin, aspirin, or digitalis, were discovered&hellip;<\/p>","protected":false},"author":1,"featured_media":0,"parent":133,"menu_order":20,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>SF-2011-Drug Development in the 21st century \u2013 are we going to cure all diseases - XLAB Stiftung<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/xlab-stiftung.de\/en\/science-festival-2004-2017-2\/sf-2011-drug-development-in-the-21st-century-are-we-going-to-cure-all-diseases\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"SF-2011-Drug Development in the 21st century \u2013 are we going to cure all diseases - XLAB Stiftung\" \/>\n<meta property=\"og:description\" content=\"Prof. MD. 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Aaron CiechanoverTechnion \u2013 Israel Institute of Technology Haifa, Israel Many important drugs such as penicillin, aspirin, or digitalis, were discovered&hellip;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/xlab-stiftung.de\/en\/science-festival-2004-2017-2\/sf-2011-drug-development-in-the-21st-century-are-we-going-to-cure-all-diseases\/\" \/>\n<meta property=\"og:site_name\" content=\"XLAB Stiftung\" \/>\n<meta property=\"article:modified_time\" content=\"2023-02-08T13:23:11+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/xlab-stiftung.de\/science-festival-2004-2017-2\/sf-2011-drug-development-in-the-21st-century-are-we-going-to-cure-all-diseases\/\",\"url\":\"https:\/\/xlab-stiftung.de\/science-festival-2004-2017-2\/sf-2011-drug-development-in-the-21st-century-are-we-going-to-cure-all-diseases\/\",\"name\":\"SF-2011-Drug Development in the 21st century \u2013 are we going to cure all diseases - XLAB Stiftung\",\"isPartOf\":{\"@id\":\"https:\/\/xlab-stiftung.de\/#website\"},\"datePublished\":\"2023-02-08T13:23:10+00:00\",\"dateModified\":\"2023-02-08T13:23:11+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/xlab-stiftung.de\/science-festival-2004-2017-2\/sf-2011-drug-development-in-the-21st-century-are-we-going-to-cure-all-diseases\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/xlab-stiftung.de\/science-festival-2004-2017-2\/sf-2011-drug-development-in-the-21st-century-are-we-going-to-cure-all-diseases\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/xlab-stiftung.de\/science-festival-2004-2017-2\/sf-2011-drug-development-in-the-21st-century-are-we-going-to-cure-all-diseases\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Startseite\",\"item\":\"https:\/\/xlab-stiftung.de\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Science Festival 2004-2023\",\"item\":\"https:\/\/xlab-stiftung.de\/science-festival-2004-2017-2\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"SF-2011-Drug Development in the 21st century \u2013 are we going to cure all diseases\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/xlab-stiftung.de\/#website\",\"url\":\"https:\/\/xlab-stiftung.de\/\",\"name\":\"XLAB Stiftung\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/xlab-stiftung.de\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/xlab-stiftung.de\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/xlab-stiftung.de\/#organization\",\"name\":\"XLAB Stiftung\",\"url\":\"https:\/\/xlab-stiftung.de\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/xlab-stiftung.de\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/xlab-stiftung.de\/wp-content\/uploads\/2023\/01\/ezgif.com-gif-maker-5.gif\",\"contentUrl\":\"https:\/\/xlab-stiftung.de\/wp-content\/uploads\/2023\/01\/ezgif.com-gif-maker-5.gif\",\"width\":2048,\"height\":230,\"caption\":\"XLAB Stiftung\"},\"image\":{\"@id\":\"https:\/\/xlab-stiftung.de\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"SF-2011-Drug Development in the 21st century \u2013 are we going to cure all diseases - XLAB Stiftung","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/xlab-stiftung.de\/en\/science-festival-2004-2017-2\/sf-2011-drug-development-in-the-21st-century-are-we-going-to-cure-all-diseases\/","og_locale":"en_US","og_type":"article","og_title":"SF-2011-Drug Development in the 21st century \u2013 are we going to cure all diseases - XLAB Stiftung","og_description":"Prof. MD. 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